Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium
نویسندگان
چکیده
منابع مشابه
Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium.
BACKGROUND Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. AIMS To establish a new colitis associated neoplasia model in p53 deficient mice by treatment with dextran sulphate sodium (DSS). METHODS DSS colit...
متن کاملINFLAMMATORY BOWEL DISEASE Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium
Background: Several animal models for human ulcerative colitis (UC) associated neoplasia have been reported. However, most neoplasias developed in these models have morphological and genetic characteristics different from UC associated neoplasia. Aims: To establish a new colitis associated neoplasia model in p53 deficient mice by treatment with dextran sulphate sodium (DSS). Methods: DSS coliti...
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One of the main treatments currently used in humans to fight cancer is chemotherapy. A huge number of compounds with antitumor activity are present in nature, and many of their derivatives are produced by microorganisms. However, the search for new drugs still represents a main objective for cancer therapy, due to drug toxicity and resistance to multiple chemotherapeutic drugs. In animal models...
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ژورنال
عنوان ژورنال: Gut
سال: 2004
ISSN: 0017-5749
DOI: 10.1136/gut.2003.028779